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Morphological Study of Cardiotoxicity in Adriamycin Treated Rats.

Journal of the Korean Pediatric Society 1989;32(8):1117-1222.
Published online August 31, 1989.
Morphological Study of Cardiotoxicity in Adriamycin Treated Rats.
H W Shin, J Y Kim, C U Joo, P H Hwang, J S Kim
Department of Pediatrics, College of Medicine, Chonbug National University, Chonju, Korea
백서에서 Adriamycin의 심장 독성에 관한 형태학적 연구
신형원, 김자영, 주찬웅, 황평한, 김정수
전북대학교 의과대학 소아과학교실
Received: 25 January 1989   • Accepted: 7 March 1989
This experiment was carried out to investigate the morphological changes of cardiac tissue in Adriamycin treated rats. Adriamycin was administered (2.5 mg/kg/wk) for 5 weeks, subcutaneously. Cardiac tissue stained by H-E and Trichrom’s method. Clinical findings of congestive heart failure were also observed during experiment. The results were as follows ; 1) Symptoms and signs of congestive heart failure (tachypnea, ascites, hepatomegaly) were appeared in 43% (6 out of 14 rats) of Adriamycin treated rats. 2) Histopathologic changes of myocardium were local and observed in subendocardial lesion of interventricular septum and anterolateral papillary muscle of left ventricle. 3) Histopathologic findings were hydrophic degenerative changes of myocardium and focal proliferation of fibrous tissue.
Key Words: Adriamycin, Histopathologic Finding, Cardiomyopathy

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