| Changes of Plasma Atrial Natriuretic Peptide and Antidiuretic Hormone in Congenital Heart Disease. |
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Sun Jun Kim, Jong San Lee, Chan Uhng Joo, Dae Yeol Lee, Jung Soo Kim |
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Department of Pediatrics, College of Medicine, Chonbuk National University, Chonju, Korea |
| 선천성 심장질환에서 혈장 Atrial Natriuretic Peptide 및
Antidiuretic Hormone의 변화 |
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김선준, 이종산, 주찬웅, 이대열, 김정수 |
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전북대학교 의과대학 소아과학교실 |
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Received: 25 January 1989 • Accepted: 7 March 1989 |
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| Abstract |
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Human atrial myocytes secrete atrial natriuretic peptides (ANP) into the plasma, which causes
rapid and marked natriuresis, diuresis and vasorelaxation. The releases of renin, aldosterone, and
antidiuretic hormone are inhibited by ANP in vivo and in vitro experiments. Various atrial natriur-
etic peptides were isolated and synthesized. Plasma ANP concentrations usually elevated in conges-
tive heart failure, chronic renal failure, pulmonary arterial hypertension, tachyarrhythmia, and
nephrotic syndrome.
However, there are a few reports about the plasma ANP concentration in child with congenital
heart disease. Furthermore, The relationship between the plasma ANP and hemodynamic status was
not investigated, sufficiently. So we measured the plasma ANP, ADH, and osmolality in peripheral
vein and right atrium in congenital heart disease during cardioangiography using nonionic contrast
media, the results were as follows:
1) Plasma ir-ANP concentration was significantly elevated in congenital heart dissase than control
group (P<0.05). The plasma ir-ANP levels in patient with congenital heart disease were correlated
with Qp:Qs (P < 0.05).
2) No significant difference in ir-ANP levels was observed between right atrium and peripheral
vein, but higher levels of ir-ANP were observed in right atrium.
3) Plasma ADH levels in congenital heart disease group were higher than in control group (P<0.
05).
4) After cardioangiography, the plasma ir-ANP levels were decreased but plasma ADH，osmolality
levels were increased, significantly. |
| Key Words:
Atrial natriuretic peptide, Antidiuretic hormone |
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