| Predictive Capacity of Cord Serum IgE for Developement of Atopy. |
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Hye Ran Byun, Hye Won Lee, Keun Lee |
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Department of Pediatrics, College of Medicine, Ewha Womans University Hospital, Seoul Korea |
| 아토피 질환 발생 예견인자로서의 제대혈청
IgE에 대한 고찰 |
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변혜란, 이혜원, 이근 |
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이화대학교 의과대학 소아과학교실 |
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Received: 9 September 1988 • Accepted: 9 September 1988 |
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| Abstract |
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The incidence of atopic disease has increased in recent years and its symptom begins early in life,
in many cases during the first year.
It is desirable, therefore, to predict the development of atopic disease early in infancy, preferably
in neonatal period, so that it can be prevented or, at least, lessened in symptoms by proper management.
One hundred and two fullterm newborn babys, born at Ewha Womans University Hospital were
investigated; their cord serum IgE levels were measured by ovemight PRIST test using RAST tracer
and they were followed up for allergic symptoms by telephone contact or clinic visit.
The geometric mean of cord serum IgE of 102 newborns was 0.80 IU/ml. There was no significant
differences of cord serum IgE levels between male and female. Serum IgE was significantly higher in
newborns with positive family history. Cord serum igE levels of 16 cases who developed atopic
symptoms were 24.46 IU/ml, significantly higher than those of non-atopic group, 1.12 IU/ml.
37.5% of newborns whose cord serum IgE levels were above 1.79 IU/ml(mean + ISD) and 27.7% of
those below 1.79 IU/ml have developed atopic syrnpoms, and the difference was statistical1y significant.
50% of newboms whose cord serurn IgE level were above mean + ISD and who also had positive
family history of al1ergy developed atopic symptoms during infancy.
The level of cord serum IgE along with family history could be regarded as an important parameter
which can predict the development of atopic disease. |
| Key Words:
Cord serum IgE, Atopy |
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