| High-Dose Cytosine Arabinoside (HD Ara-C) Therapy for Refractory Acute Leukemia in Children. |
|
Il Soo Ha, Hyo Seop Ahn, Chang Yee Hong |
|
Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea |
| 소아의 치료불응성 급성 백혈병에서의
고용량 Cytosine Arabinoside 요법 |
|
하일수, 안효섭, 홍창의 |
|
서울대학교 의과대학 소아과학교실 |
|
Received: 28 December 1987 • Accepted: 28 May 1988 |
|
|
| Abstract |
|
Eleven children with refractory acute leukemia were treated with high dose cytosine arabinoside
(HD Ara-C), given at a dosage of 3 gm/m2 intravenously over about one hour every 12 hours for four
to eight doses. The antileukemic effects were evaluable in nine of the patients, two with ALL, seven
with ANLL. Six of the seven patients with ANLL attained complete remission, while neither of the two
patients with ALL entered remission after the treatment. Significant bone marrow depression and
fever followed the treatment in all patients, requiring intensive supportive cares. Pneumonia, urinary
tract infection and sepsis were the most frequently documented infectious complications. Various
nonhematologic toxicities, such as nausea, vomiting, hepatic dysfunction, diarrhea, skin rash and
conjuctivitis, were noted in the given order of frequency, but central nervous system toxicity was not
observed. Of the six patients who entered complete remission, two patients relapsed seven and forty
seven weeks after remission respectively, and the other four patients are still in continuous remission
for 14 + ~ 46 + weeks.
We conclude that HD Ara-C therapy, in this author’s method, is an effective alternative regimen
with relatively tolerable toxicities in children with refractory acute leukemias, especially ANLL. |
| Key Words:
Refractory acute leukemia, High dose cytosine arabinoside |
|
PDF Links
Download Citation
