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Non-specific Immunotherapy with Histamine-Gammalobulin Preparations in Chronic Respiratory Group Patients and Non-atopic Asthmatic Children.

Journal of the Korean Pediatric Society 1988;31(10):1308-1314.
Published online October 31, 1988.
Non-specific Immunotherapy with Histamine-Gammalobulin Preparations in Chronic Respiratory Group Patients and Non-atopic Asthmatic Children.
Byeung Ju Jeoung, Kyu Earn Kim, Ki Young Lee
Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea
만성 호흡기질환군 및 비아토피성 천식환아에서 Histamine-Gammaglobulin 제제로 실시한 비특이적 면역요법
정병주, 김규언, 이기영
연세대학교 의과대학 소아과학교실
Received: 27 April 1988   • Accepted: 27 April 1988
Abstract
We evaluated the therapeutic effect of non-specific immunotherapy with Histamine- gammahlobulin in 60 patients. Among them 22 patients were chronic respiratory group patients who were under 2 years of age and suffered from frequent respiratory tract infections, and 38 patients were as follows: 1) Excluding the patients who received 9 weeks therapy for the test period, the mean duration of Histamine-gammaglobulin therapy in the chronic respiratory group patients(9.4 months) was shorter than that of the non-atopic asthmatic children(21.1 months). We suggest that the latter disease presents more involved and troublesome problems to the patients and their parents. 2) There was clinical improvement in 63.6% of the chronic respiratory group patients after Histmine-gammaglobulin therapy; 18.2% of the patients exhibited excellent improvement and good and fair results were each seen in 22.7% of the patients, respectively. The patients who exhibited good to excellent improvement received Histamine-gammaglobulin therapy for approximately 1 year. 3) There was clinical improvement in 52.6% of the non-atopic asthma patients after Histamine- gammaglobulin therapy; 21.1% of the patients showed excellent improvement, 18.4% good and 13.1% fair. There was no significant correlation between the effecacy of Histamine-gammaglobulin therapy and the severity of asthma. 4) We evaluated the efficacy of Histamine-hammaglobulin therapy on 14 non-atopic asthmatic children who were treated for more than one year. At the short term follow-up, after 9 injections, excellent results were seen in only 2 patients but at the long term follow-up, excellent results were noted in 5 patients. Good and fair results at the short term follow-up were seen in 8 and 4 patients, but at the long term follow-up, after about 27 months of therapy, this changed to 4 and 2 patients, respectively. There were 3 patients who presented good results at the short term follow-up, but at the long term follow-up, after about 22 months of therapy, this changed to not effective. Histamine-gammaglobulin therapy appered to be effective in both the chronic respiratory group patients and the non-atopic asthmatic children, if the pateint was selected properly. The efficacy of Histamine-gammaglobulin therapy is better determined after long term follow-up.
Key Words: Histamine-gammaglobulin, Chronic respiratory group, Non-atopic asthma


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