| Lipoproteinelectropheresis pattern in Nephrotic Syndrome. |
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Soon Don Hong1, Byung Soo Cho1, Chang Il Ahn1 |
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| 신증후군 환아들에서의 혈청지질 단백의 전기영동 분획상 |
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홍순돈1, 조병수1, 안창일1 |
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Received: 13 February 1988 • Accepted: 9 May 1988 |
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| Abstract |
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This study was undertaken to eluidate lipoprotein patterns in patients with childhood nephrotic
syndrome by response to initial steroid therapy, serum albumin level in MCNS and other histologic
classifications.
The result were summerized as follows.
1) There were 19 cases (52.8%) of abnormal lipoprotein patterns by Fredrickson classifications, type
Ila were 6 cases (16.7%), type lib were 1 cases (2.8%) and type IV were 12 cases (33.3%) respectively.
2) In non-biopsy group, but suspected to MCNS by clinical finding, laboratory data and response to
steroid therapy, abnormal lipoprotein patterns were 6 of 12 cases (50.9%), type Ila were 2 cases (11.7
%) and type IV were 4 cases (33.3%) respectively.
Biospy was done and confirmed to MCNS, abnormal lipoprotein patterns were 10 of 17 cases (50.8
%), type Ila were 2 cases (11.7%), type lib were 1 case (5.9%) and type IV were 7 cases (41.2%)
respectively.
3) The lipoprotein patterns in response to inital steroid therapy in poor response group; normal
patterns were 2 cases (40.0%), type Ila were 2 cases (40.0%) and type IV were 1 case (20.0%) In partial
remission group; normal patterns were 7 cases (38.9%), type Ila were 2 cases (11.1%), type lib were 1
case (5.5%) and type IV were 8 cases (44.4%). In complete remision group; normal patterns were 5 cases
(83.3%) and type IV were 1 case (16.7%) respectively.
4) The composition percentage of lipoprotein in response to initial steroid therapy, in poor response
group; HDL was 29.89±8.65(%), VLDL was 15.0±8.40(%) and LDL was 55.29± 6.91(%) respectively. In
complete remission group; HDL was 27.7±7.11(%), VLDL was 18.28±6.09(%) and LDL was 54.00±3.
92(%), respectively.
5) The relationship between serum albumin level and lipoprotein patterns in childhood nephrotic
syndrome, increase percentage of normal lipoprotein patterns and decrease type IV proportion in high
serum albumin level. |
| Key Words:
Lipoproteinelectropheresis patterns, Nephrotic Syndrome |
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