| ABO Gene Frequency in ABO Hemolytic Disease of Newborn. |
|
Young Mi Hong, Keun Lee |
|
Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, Korea |
| 신생아의 ABO 용혈성 질환에서의 ABO 유전자
빈도에 관한 연구 |
|
홍영미, 이근 |
|
이화대학교 의과대학 소아과학교실 |
|
Received: 13 January 1988 • Accepted: 24 March 1988 |
|
|
| Abstract |
|
ABO hemolytic disease in newborn due to ABO incompatibility between mother and infant is one of
common cause of neonatal hyperbilirubinemia and early detection has been emphasized due to its
possible neurologic sequelae. Many studies reported prevalence difference of ABO hemolytic disease
in various races, which could be ascribed to different frequency of ABO genes in races.
From Feb. 1986 to May 1987 full term newborns were screened and 447 cases with jaundice were
studied.
1) ABO compatible cases were 357 (79.9%) and ABO incompatible cases 90 (20.1%). O—A was 52
cases, and O—B 38 cases.
2) Mean appearance time of jaundice was significantly earlier in ABO incompatible group than ABO
compatible group.
3) Reticulocyte count was significantly higher in ABO incompatible group than ABO compatible
guoup.
4) The frequency of A gene was 0.274, B 0.195 and O 0.531. ABO gene frequency of Korean was
similar to that of the Japanese. But when it was compared to American, A and B gene were more
frequent.
5) Incidence of ABO incompatible pregnancy was 20.1%
6) Incidence of ABO hemolytic disease due to ABO incompatibility was 1.36%. It was similar to the
Japanese and the white, but significantly lower than the black.
In conclusion, the difference of ABO gene frequency in various races cannot exj^ain the difference
of ABO hemolytic disease incidence, especially between Korean and Caucasian or black races. |
| Key Words:
ABO Gene frequency, Hemolytic disease |
|
PDF Links
Download Citation
