| A Prospective Study of Urinary beta2 -Microglobulin in Infants with Meconium-Stained Amniotic Fluid. |
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Sung Oh Kim, Jeh Hoon Shin, Woo Gill Lee, Soo Jee Moon, Keun Soo Lee |
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Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea |
| 태변에 착색된 신생아에서의 소변
β2- Microglobulin 에 관한 연구 |
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김성오, 신재훈, 이우길, 문수지, 이근수 |
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한양대학교 의과대학 소아과학교실 |
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Received: 20 June 1988 • Accepted: 1 August 1988 |
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| Abstract |
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We studied prospectively whether events that result in meconium staining may be associated with
additional abnormalities that are not clinically apparent associated by measurements of urinary
concentrations of β₂-microglobulin indicating renal proximal tubular functions.
Among 61 fullterm, healthy neonates delivered at Hanyang University Hospital during the period
of September 1986 through April 1987, urinary concentration of β₂-microglobulin and creatinine were
measured during the immediate perinatal period. Of these, 39 had meconium stained amniotic fluid;
the remaining 22 had clear amniotic fluid. None of the infants or their mothers had conditions known
to modify urinary β₂-microglobulin
The following results were obtained:
1) Urinary β₂-microglobulin concentrations increased significantly in the normal infants (p< 0.002)
from the 1st day (0.58±0.13 mg/L) to the 3rd day (1.39 ±0.21 mg/L) postpartum, also in the infants
with meconium stained aminiotic fluid (p<0.014) from the 1st day (3.59±0.47 mg/L) to the 3rd day (5.
17 ±0.44 mg/L) postpartum.
2) Compared with the normal infants, values for the infants with meconium stained amniotic fluid
were increased significantly both on day 1 and 3 postpartum (p< 0.0001).
3) Urinary creatinine levels were also declined from the 1st day to the 3rd day postpartum in both
the normal infants and those with meconium stained amniotic fluid but compared with normal
infants, values for the infant with meconium stained amniotid fluid were not increased significantly
on day 1 and 3 postpartum.
4) Creatinine ratio for β₂-microglobulin were also increased significantly from the 1st day to the 3rd
day postpartum both in the normal infants (1.85 ± 0;51->5.94 ± 1.02 /µg/mg, p< 0.001) and in the infants
with the meconium stained amniotic fluid (6.94 ±0.83->15.34 ±1.53 µg/mg, p< 0.0001). Comparison
between the normal infants and the infants with the meconium stained amniotic fluid were increased
significantly on days 1 and 3 postpartum (p< 0.0001).
5) The elevated levels of urinary β₂-microglobulin in the infants with meconium stained amniotic
fluid indicates the existence of renal tubular dysfunction. |
| Key Words:
Urinary β₂-microglobulin, Renal proximal tubular dysfunction, Meconium-stained amniotic fluid |
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