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Clinical Characteristics and Pathogenesis of Typhlitis in Childhood Non-Lymphocytic Leukemia-Considerations on Clinical Mangement with Report of Two Cases and Literature Review.

Journal of the Korean Pediatric Society 1988;31(5):607-620.
Published online May 31, 1988.
Clinical Characteristics and Pathogenesis of Typhlitis in Childhood Non-Lymphocytic Leukemia-Considerations on Clinical Mangement with Report of Two Cases and Literature Review.
Do Hyun Kim1, Sung Oh Kim1, Soo Yup Lee1, In Joon Seol1, Hahng Lee1, Chong Moo Park1, Poong Man Jung2, Seok Chol Jeon3, Young Hyeh Ko4, Jung Dal Lee4
소아급성골수성백혈병에서 발생한 Typhlitis의 임상양상과 발생기전의 조사 분석
김도현1, 김성오1, 이수엽1, 설인준1, 이항1, 박종무1, 정풍만2, 전석철3, 고영혜4, 이중달4
Received: 4 November 1987   • Accepted: 30 December 1987
Abstract
The treatment of acute leukemia in childhood has been increasingly successful due to progression of chemotherapeutics and other supportive care. Improved survival rates in acute childhood leukemia have been associated with an increasing number of complications in the gastrointestinal tract. Typhlitis also known as ileocecal syndrome is a necrotizing inflammation of the cecum in leukemic patients on chemotherapy in the terminal stage of the disease and is often associated with neutropenia. Once the ileocecal complication developed, the prognosis was grave. The authors experienced two cases of typhlitis among acute non-lymphocytic leukemia patients receiving chemotherapy. The clinical, roentgenographic findings, operative findings, pathologic findings and outcomes are presented with the review of the literature on the subject. The importance of recognizing this entity is emphasized because early detection with high index of suspicion might provide better treatment and may alter the prognosis. Authors investigated the diagnostic findings of typhlitis and attempted to provide early diagnostic criteria, and the factors to improve the therapeutic outcome of typhlitis are suggested.
Key Words: Typhlitis, Acute leukemia, Chemotherapy, Neutropenia


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