| Clinical Study on Growth Hormone Deficient Dwarfs. |
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Duk Hi Kim |
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Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea |
| 성장호르몬 결핍성 왜소증에 관한 연구 |
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김덕희 |
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연세대학교 의과대학 소아과학교실 |
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Received: 23 December 1987 • Accepted: 31 December 1987 |
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| Abstract |
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34 patients with growth hormone (GH) deficiency were studied. The affected males outnumber
females in a proportion of 1.8 to 1. The chronological ages on diagnosis was average 9.4 years old
and bone age was delayed with average 6.6 years old.
The major cause of GH deficiency was idiopathic and organic causes such as craniopharyngioma,
germinoma & Tb. meningitis were relatively uncommon.
Cerebral anoxia seemed to be major influencing factor in the idiopathic GH deficiency.
In case of idiopathic, isolated GH deficinecy was 82.8% and multiple pituitary hormone deficiency
17.2%. In case of organic lesion, multiple hormone deficiency was 100%.
There was no difference in height between those with isolated GH & multiple pituitary hormone
deficiency.
The twelve patients were treated with GH lasting 6 months to 27 months. During GH therapy
(0.06—0.1 U/kg), yearly growth velocity was increased from 2.49 cm to 7.56 cm in first & 7.40 cm
in second year. There was no significant bone age advancement compare to chronological age.
The eleven patients were treated with oxandrolone lasting 6 to 24 months. During oxandrolone
therapy (0.25 mg/kg) yearly growth velocity was increased from 2.29 cm to 6.24 cm in first & 6.17
cm in second year.
There was no statical difference in yearly growth velocity between GH and oxandrolone treated
group. But there is a tendency in bone age acceleration in oxandrolone treated group. The
acceleration in bone age suggested the need for further long-term studies in oxandrolone therapy. |
| Key Words:
Dwarfism, Hypopituitarism, Growth hormone deficinecy, Growth hormone therapy,
Oxandrolone therapy |
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