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Burkitt Lymphoma in Children.

Journal of the Korean Pediatric Society 1988;31(4):482-491.
Published online April 30, 1988.
Burkitt Lymphoma in Children.
Soo Jong Hong1, Dong Kyu Jin1, Hee Young Shin1, Hyo Seop Ahn1, Chang Yee Hong1, Je G Chi2
1Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
2Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea
소아의 버키트 림프종
홍수종1, 진동규1, 신희영1, 안효섭1, 홍창의1, 지제근2
1서울대학교 의과대학 소아과학교실
2서울대학교 의과대학 병리학교실
Received: 29 September 1987   • Accepted: 24 November 1987
Seventeen cases of Burkitt lymphoma under 15 years of age who were admitted to Dept, of Ped., Seoul National University Hospital from Jan. 1979 to Dec. 1986 were reviewed and analysed. One hundred and six cases of non-Hodgkin lymphoma were seen during the same period. 1) Burkitt lymphoma accounted for 16% of non-Hodgkin lymphoma. 2) The age ranged from 10/12 year to 15 5/12 years, with mean age of 6 years. 3) The ratio of male to female was 3.3:1 and boys were more prevalent than girls. 4) Involed sites were abdomen in 14 cases, head and neck in 6 cases, ovary and uterus in 3 cases, CNS in 3 cases, bone in 1 case, pleural fluid in 4 cases, and ascites in 3 cases. 5) Clinical stage by Murphy’s classification consisted of 2 stage Ⅰ (11.8%), 2 stage Ⅱ(11.8%), 4 stage Ⅲ (23.5%), 9 stage Ⅳ (52.9%). 6) Bone marrow involvement at initial diagnosis was seen in 8 out of 17 cases (47.1%) and CNS involvement was seen in 2 out of 14 cases (14.3%). 7) Treatment consisted of 6 chemotherapy only, 6 chemotherapy and radiation therapy, and 3 surgery and chemotherapy and/or radiation therapy. Remission rate was 80% and relapse rate was 42%. The longest relapse free survival time was 4 4/12 years, and 4 cases survived over one year without relapse. Acute tumor lysis syndrome was seen in 8 cases, but 4 cases survived.
Key Words: Burkitt lymphoma, Non-Hodgkin lymphoma, COMP, Ziegler classification, Murphy classifi- cation, Acute tumor lysis syndrome, Relapse free survival time

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