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Chronic Hepatitis B in Children.

Journal of the Korean Pediatric Society 1987;30(10):1115-1123.
Published online October 31, 1987.
Chronic Hepatitis B in Children.
Don Gyu Yang, Jong Kyun Lee, Pyung Kil Kim, Chang Ho Hong, Chul Lee
Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea
소아의 만성 B형 간염에 대한 임상적 고찰
양돈규, 이종균, 김병길, 홍창호, 이 철
연세대학교 의과대학 소아과학교실
We reviewed 19 cases of chronic hepatitis B confirmed by liver biopsy during the 3 years and 5months from March 1983 to July 1986 at Young Dong Severance Hospital. The following results were obtained: 1) There were 16 boys and 3 girls with ages ranging from 7 months to 14 years old (mean+S.D.; 6.5 ±0.9 years). 2) There were 2 cases (10.5%) of chronic persistent hepatitis (CPH) and 17 cases (89.5%) of chronic active hepatitis (CAH). 3) The chief complaint was hepatitis for more than 6 months duration (47.4%), and the main physical finding was hepatomegaly (57.8%). 4) Laboratory results included the followings. All cases were HBs Ag (+), and anti-HBe (+),the levels of SGOT were 122.1 ±26.1 unit/l(mean±S.D.), of SGPT were 210 ±53.7 unit/1, and of DNA polymerase were 1,897.1 ±657.1 dpm/ml. 5) Liver cirrhosis was combined with CAH in 5 cases (29.4%) and associated with persistent high antigenemia, natural seroconversion, a significant family history of liver cirrhosis or hepatocellular carcinoma. 6) After adenine arabinoside (ARA-A) therapy for chronic active hepatitis, seroconversion was demonstrated in 2 cases (15.4%) and transaminase resolution was seen in 8 cases (61.5%) within 8.1 ±1.7 onths.
Key Words: Chronic hepatitis B, Adenine arabinoside

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