| Chronic Hepatitis B in Children. |
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Don Gyu Yang, Jong Kyun Lee, Pyung Kil Kim, Chang Ho Hong, Chul Lee |
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Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea |
| 소아의 만성 B형 간염에 대한 임상적 고찰 |
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양돈규, 이종균, 김병길, 홍창호, 이 철 |
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연세대학교 의과대학 소아과학교실 |
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| Abstract |
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We reviewed 19 cases of chronic hepatitis B confirmed by liver biopsy during the 3 years and 5months from March 1983 to July 1986 at Young Dong Severance Hospital.
The following results were obtained:
1) There were 16 boys and 3 girls with ages ranging from 7 months to 14 years old (mean+S.D.; 6.5 ±0.9 years).
2) There were 2 cases (10.5%) of chronic persistent hepatitis (CPH) and 17 cases (89.5%) of chronic active hepatitis (CAH). 3) The chief complaint was hepatitis for more than 6 months duration (47.4%), and the main
physical finding was hepatomegaly (57.8%). 4) Laboratory results included the followings.
All cases were HBs Ag (+), and anti-HBe (+)，the levels of SGOT were 122.1 ±26.1 unit/l(mean±S.D.), of SGPT were 210 ±53.7 unit/1, and of DNA polymerase were 1,897.1 ±657.1 dpm/ml.
5) Liver cirrhosis was combined with CAH in 5 cases (29.4%) and associated with persistent high
antigenemia, natural seroconversion, a significant family history of liver cirrhosis or hepatocellular carcinoma.
6) After adenine arabinoside (ARA-A) therapy for chronic active hepatitis, seroconversion was
demonstrated in 2 cases (15.4%) and transaminase resolution was seen in 8 cases (61.5%) within 8.1 ±1.7 onths.
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| Key Words:
Chronic hepatitis B, Adenine arabinoside |
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