| A Study on Serum Ca, P, Mg, Parathyroid Hormone, Calcitionin, and 1, 25-dihydroxyvitamin D Concentrations in Normal Newborn and Low Birth Weight Infants. |
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In Bock Lee, Chang Soo Ra |
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Department of Pediatrics, College of Medicine, Chosun University |
| 신생아에 있어서 혈청 Ca ,P, Mg치와Parathyroid Hormone, Calcitonin 및 1, 25-dihydroxyvitamin D치에 관한 연구
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이인복, 나창수 |
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조선대학교 의과대학 소아과학교실 |
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| Abstract |
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Early neonatal hypocalcemia occurs within the first few days of life, with the lowest concentrations
of serum calcium being reached at 24 to 48 hours of age. An infant can be considered to be
hypocalcemic when serum calcium concentrations are below 7 mg/dl or when ionized calcium
concentrations are below 3 to 3.5 mg/dl. The most commonly encountered causes of neonatal
hypocalcemia are prematurity, birth asphyxia, and infants of mothers with diabetes. Early neonatal
hypocalcemia appears to be related to decreased calcium intake in associated with temporaly
neonatal hypoparathyroidism, possible hypercalcitonemia, and in some instances, possible disorders
vitamin D metabolism. To investigate the influence of parathyroid hormone, calcitonin, and 1,25-dihydroxyvitamin D for calcium concentrations in the newborn infants, authors studied serum calcium, phosphorus, magnesium, parathyroid hormone, calcitonin, and 1,2 5-dihy dr oxy vitamin D concentrations in 20 cases of
normal newborn infants and their mothers at delivery, and in 9 cases of normal newborn infants and
in 7 cases of low birth weight infants during the first five days of life.
The following results were obtained:
1) The mean serum calcium levels of cord blood in 20 cases of normal newborn infants were 10.46 ±0.88 mg/dl and those of maternal blood in 20 cases of the mothers were 9.21 ±0.85 mg/dl. In comparison of serum calcium levels for the normal newborn and the mother, the serum calcium levels of the newborn infants were significantly higher than those of mothers(p < 0.005).
2) The mean serum phosphorus levels of cord blood in 20 cases of normal newborn infants were 6.08±1.67 mg/dl and those of maternal blood in 20 cases of the mothers were 4.56±1.89 mg/dl. In comparison of serum phosphorus levels for the normal newborn and the mothers, the serum phosphorus levels of the newborn infants were significantly higher than those of the mothers(p < 0.005).
3) The mean serum magnesium levels of cord blood in 20 cases of normal newborn infants were 2.01 ±0.45 mg/dl and those of maternal blood in 20 cases of the mothers were l,67±0.19 mg/dl.
Incomparison of serum magnesium levels for the newborn and the mother, the serum magnesium levels
of the newborn infants were significantly higher than those of the mothers(p < 0.005).
4) The mean serum parathyroid hormone levels of cord blood in 20 cases of normal newborn infants
were 56.1 ±65.0 pg/ml and those of maternal blood in 20 cases of the mothers were 104.5± 146.8 pg/ml.
In comparison of serum parathyroid hormone levels for the normal newborn and the mothers, the
serum parathyroid hormone levels of the normal newborn infants were significantly lower, than those
of the mothers(p<0,01).
5) The mean serum calcitonin levels of cord blood in 20 cases of normal newborn infants were 60.6±44.2 pg/ml and those of maternal blood in 20 cases of the mothers were 28.1 ±27.1 pg/ml. In
comparison of serum calcitonin levels for the normal newborn and the mother, the serum calcitonin
levels of the normal newborn infants were significantly higher than those of the mothers(p<0.01).
6) The mean serum 1,25-dihydroxyvitamin D levels of cord blood in 20 cases of normal newborn
infants were 28.6±13.6 pg/ml and those of maternal blood in 20 cases of the mothers were 42.1 ±3.0.
In comparison of serum 1,25-dihydroxyvitamin D levels for the normal newborm and the mothers, the
serum 1,25-dihydroxyvitamin D levels of the newborn infants were lower than those of the mothers,
however, statistically not significant(p > 0.2).
7) The mean serum calcium levels in 9 cases of normal newborn infants at the first, third and fifth
days of life were 9.28±1.26 mg/dl, 8.68±1.09 mg/dl, and 9.07±1.14 mg/dl respectively, and the those
in 7 cases of low birth weight infants were 7.67 ±1.84 mg/dl, 8.71 ±1.11 mg/dl, and 8.50 ±0.87 mg/dl respectively.
8) The mean serum parathyroid hormone levels in 9 cases of normal newborn infants at the first,
third and fifth days of life were 84.6±48.5 pg/ml, 88.3±52.7 pg/ml, and 161.1 ±140.4 pg/ml respectively, and those in 7 cases of low birth weight infants were 57.8±23.1 pg/ml, 68.5±55.0 pg/ml, and 121.1 ± 106.8 pg/ml respectively.
9) The mean serum calcitonin levels in 9 cases of normal newborn infants at the first, third and fifth
days of life were 69.9±52.2 pg/ml, 71.6±52.7 pg/ml, and 86.6±68.3 pg/ml respectively, and those in 7
cases of low birth weight infants were 61.8±49.6 pg/ml, 83,0±53.4 pg/ml, and 86.6±68.3 pg/ml respectively.
10) The mean serum 1,25-dihydroxyvitamin D levels in 9 cases of normal newborn infants at the
first, third and fifth days of life were 46.0 ±19.3 pg/ml, 33.2 ±17.3 pg/ml, and 49.0 ±33.9 pg/ml respec-
tively, and those in 7 cases of low birth weight infants were 29.6±8.2 pg/ml, 46.2±19.3 pg/ml, and 47.2±15.2 pg/ml respectively.
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| Key Words:
Serum Ca, P, Mg, PTH, Calcitonin, 1,25-dihydroxyvitamin D levels, newborn infants |
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