| Clinico-Hematologic Observation of Neonatal Hemolytic Disease due to Minor Blood Group Isoimmunization. |
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Chong Woo Bae1, Yong Mook Choi1, Chang Il Ahn1, Hyun sok Chi2 |
1Department of Pediatrics, School of Medicine, Kyung Hee University
2Department of Clinical Pathology, School of Medicine, Kyung Hee University |
| Minor Blood Group에 의한 신생아 동종 면역성 용혈성 질환의 임상，혈액학적 관찰
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배종우1, 최용묵1, 안창일1, 지현숙2 |
1경희대학교 의과대학 소아과학교실
2경희대학교 의과대학 임상병리학교실 |
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| Abstract |
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The isoimmune hemolytic diseases of the newborn due to minor blood group are characterized by
the abnormal titer of minor group antibody in mother’s serum and neonatal progressive jaundice
caused by isoimmune hemolytic anemia.
This report present the clinico-hematologic features of six cases of hemolytic diseases of newborn
due to minor blood group isoimmunization who were admitted to the Kyung Hee university Hospital
and presented with jaundice and anemia.
The following results were obtained;
1) Neonatal jaundice was observed immediately after birth in 5 cases, the other one case aged 2.5 months was
noted severse anemia on admission.
2) Total bilirubin levels were 12.5〜40.0 mg%.
3) On antiglobulin test, positive direct reaction were revealed in all cases of patient and positive
indirect reaction were revealed in 5 cases of mother.
4) There was no evidence of ABO or Rh(D) incompatibility in all cases. All patients had E, c
antigens in blood, but mothers had no E, c antigen in blood by Rh-Hr subtyping.
5) In summary, three cases of anti-E, 2 cases of anti-c and 1 cases of anti-E or c incompatibility
were noted by selective antibody screening.
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| Key Words:
Minor blood group, Isoimmune hemolytic disease, Neonatal hyperbilirubinemia
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