| Chlorambucil Treatment in Chidren with Frequently Relapsing Minimal Lesion Nephrotic Syndrome. |
|
Myung Hee Chung, Hae Woon Chang, Haeng Mi Kim, Ja Hoo Koo |
|
Department of Pediatrics, School of Medicine, Kyungpook University Hospital, Taegu, Korea |
| 재발이 빈번한 신증후군환아에 있어서 Chlorambucil의 치료효과
|
|
정명희, 장해운, 김행미, 구자훈 |
|
경북대학교 의과대학 소아과학교실 |
|
|
|
|
| Abstract |
|
A clinical study was conducted on children with frequently relapsing nephrotic syndrome to see the
therapeutic effectiveness of chlorambucil therapy. Study population consisted of 21 children with
biopsy-proven minimal lesion nephrotic syndrome, in whom chlorambucil therapy was given to
control their frequent relapses and/or steroid dependency. Eleven patients were frequent relapser and
10 were steroid dependant. Study period extended from December 1980 to August 1985, and children
whose follow-up period was less than 1 year were excluded from this study.
The following results were obtained:
Sex distribution showed male preponderance with male to female ratio of 4.2: 1. Remission rate
after chlorambucil therapy was 66.7% at 6 months and 52.4% at 12 months.
Comparison of the remission rate lasting longer than 12 months and other various parameters which
could be related to the remission rate, such as age at onset of illness, duration of illness before
chlorambucil treatment, selectivity index of proteinuria and presence of hematuria, showed no
statistically significant differences.
However, remission lasting longer than 6 months and 12 months showed statistically significant
correlation with patient's age at the time of chlorambucil therapy. Patients with age over 6 years at
the time of chlorambucil therapy showed longer lasting remission compared to patients under 6 years
(P<0.05).
Side effects of chlorambucil therapy included 12 cases of transient leukopenia in which the lowest
level was 2,200/mm3, and few cases of nausea, vomiting, abdominal pain and impetigo.
|
| Key Words:
Frequently relapsing nephrotic syndrome, Steroid dependant nephrotic syndrome, Chlorambucil treatment.
|
|
PDF Links
Download Citation
