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Clinical Evaluation of Congenital Heart Disease in Down Syndrome.

Journal of the Korean Pediatric Society 1986;29(10):1095-1103.
Published online October 31, 1986.
Clinical Evaluation of Congenital Heart Disease in Down Syndrome.
Sang Kyu Park, Young Hoon Kim1, Son Moon Shin1, Chung Il Noh1, Jung Yun Choi1, Yong Soo Yun1, Cang Yee Hong1, Kyoo Wan Choi2, Shin Yong Moon3
1Department of Pediatrics. College of Medicine, Seoul National University
2Department of Internal Medicine, College of Medicine, Seoul National University
3Department of Obstetrics and Gynecology, College of Medicine, Seoul National University
Down증후군에 있어서의 선천성 심질환의 임상적 분석
박상규, 김영훈1, 신손문1, 노정일1, 최정연1, 윤용수1, 홍창의1, 최규완2, 문신용3
1서울대학교 의과대학 소아과학교실
2서울대학교 의과대학 내과학교실
3서울대학교 의과대학 산부인과학교실
The association of congenital heart disease in patients with Down syndrome has been recognized for nearly 100 years. A wide variety of congenital heart diseases have been identified in these patients. This is the report of clinical evaluation of 105 patients with congenital heart disease in Down syndrome, experienced at the Seoul National University Hospital, during past 6 years from Jan. 1980 to Dec. 1985. The results of observations were as follows: 1) There were 105 patients(45.4%) with heart disease among 231 infants and children with Down syndrome. 2) The most common lesions were ventricular septal defect (48.6%), endocardial cushion defect(33.3%), tetralogy of Fallot(8.6%), secundum atrial septal defect(7.6%). 3) Nineteen acyanotic patients were catheterized; 17 patients(89.5%) had pulmonaryartery hypertension and 15 patients(79%) had pulmonary vascular obstruction. 4) 63 patients were followed up in these series, and among them 20 patients (31.7%) had died. The causes of death were pulmonary complication in ten cases, congestive heart failure in four cases.
Key Words: Congenital heart disease, Down syndrome.

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