| Endogenous Digoxin-like Substance in Neonatal Serum, Pregnant Women and Placental Extracts. |
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Heon Seob Song, In Soo Choi, Dae Yeol Lee, Jung Soo Kim, Chang Beom Shin, Yong Bae Shin |
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Department of Pediatrics, Chonbuk National University Medical School |
| 신생아 및 산모혈청과 태반추출물에서 검출된 Endogenous Digoxin-like Substance 에 관한 연구
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송헌섭, 최인수, 이대열, 김정수, 신창범, 신용배 |
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전북대학교 의과대학 소아과학교실 |
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| Abstract |
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To digoxin-like substance, the authers tried to confirm the presence of this substance in cord blood,
sera from premature and full-term infants, third trimester pregnant women not receiving digoxin,
and placental extracts, and to investigate the origin and potential physiologic role of DLS, endogenous
Na+, K+-ATPase inhibitor in relation to renin activity. The results were as follows;
1) Cord sera DLS values were significantly higher than those of maternal sera, and maternal sera DLS values were significantly higher than those of adult controls. 2) There were significant correlations of DLS values between mother and baby paired sera, placental extracts and corresponding cord sera, too. 3) There were no significant correlations between DLS values from placental extracts and placental renin activities, DLS values from cord plasma and cord plasma renin activities, too. 4) After birth, DLS values decreased progressively with distinct peak, but significant levels were detected at 2 weeks of age. These results suggest that DLS probably originated from fetus near term, neonates and or placenta.
The biochemical identity and its possible physiological significance need further study.
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| Key Words:
Endogenous digoxin-like substance. |
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