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A Clinical Study on Reye's Syndrome.

Journal of the Korean Pediatric Society 1985;28(8):783-794.
Published online August 31, 1985.
A Clinical Study on Reye's Syndrome.
Hye Sun Jung, Seong Ryong Hyon, Ha Baik Lee, Soo Jee Moon, Chong Moo Park
Department of Pediatrics, College of Medicine, Hanyang University
Reye 증후군에 관한 임상적 연구
정혜선, 현승룡, 이하백, 문수지, 박종무
한양대학교 의과대학 소아과학교실
Ninety three cases of Reye's Syndrome were admitted to pediatric ward of Hanyang University Hospital during 6 year period from January 1979 to December 1984. The following results were obtained; 1)The peak age incidence was under 1 year of age. The sex incidence revealed male predominance with sex ratio 1.6 to 1(M : F). 2)The peak seasonal incidence was noted in spring and winter. 3)The most common preceding illness was URI (75.2%). 4)The clinical manifestations were as follows; unconsciousness(85.0%), palpable liver (80.6%), convulsion(71.0%), vomiting(71.0%), fever(67.7%), coughing(66.7%), diarrhea (19.4%) and respiratory difficulty(ll. 8%). 5)Biochemical laboratory data were as follows; the mean values of serum G.O.T. & serum G.P.T. were 444 unit/Z, 382 unit/Z, respectively. Blood ammonia levels were elevated in expired group. There were not significant difference between survived group and expired group. 6)The prognosis were related to age, serum ammonia, stage on admission, serum LDH and intracranial pressure. 7)Results of therapy was more significance than mannitol therapy above stage JU. 8) The overall fatality rate was 50.5%.
Key Words: Reye' s Syndrome

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