| The Study on Residual Beta-cell Function in Children with Dibetes Mellitus. |
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Duk Hi Kim |
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Department of Pediatrics,Yonsei Univ., College of Med., Seoul, Korea |
| 당뇨병환아 췌 장세포의 기능에 관한 연구 |
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金德照 |
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연세의대 소아과 |
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| Abstract |
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C-peptide can be used as a measure of endogenous insulin secretion in insulin treated diabetes mellitus.
Pancreatic p cell secretory activity was measured in 11 patients with insulin dependent and 2 patients with non insulin-dependent diabetes mellitus by means of serum C-peptide response to 1 mg of glucagon subcutaneously.
Serum C-peptide was increased to near normal range in the remission phase and decreased progressively with duration of diabetes mellitus. During the first 5 years after onset residual beta-cell function was demonstrable in
majority of insulin treated patients. Stable patients had a higher C-peptide concentration than unstable ones.
There was a positive relationship between C-peptides and age at onset but negative corrlation to duration of diabetes. There were also negative relationship between C-peptides and. fasting blood glucoses and negative correlation to HBAiC. These results suggest that early detection and intensive treatment of diabetes before
severe metabolic disturbance may help preserve pancreas beta-cell function.
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| Key Words:
Residual beta cell function, Insulin dependent DM, C-peptide |
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