Role of Enterotoxogenic E.Coli in Acute Diarrhea of Childhood in Korea. |
Kwang Wook Ko1, Jeong Kee Seo1, Woo Hyun Chang2, Moon Kyo Kim2, Nam Ung Yang2, Myoung Sik Choi2 |
1Department of Pediatrics, College of Medicine,Seoul National University 2Department of Microbiology College of Medicine,Seoul National University |
장독성 대장균에 의한 소아설사의 빈도에 관한 연구 |
고 광 욱1, 서 정 기1, 장우현2, 김문교2, 양남음2, 최명식2 |
1서울대학교 의과대학 소아과학교실 2서울대학교 의과대학 미생물학교실 |
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Abstract |
To determine the role of enterotoxigenic Escherichia coli in diarrheal disease of non-hosp-
italized children living in Korea, stool specimens were collected from 330 patients with dia-
rrhea and 68 age and sex matched control.
Sixty-eight healthy children and 330 diarrheal patients, who visited three private clinics
and one municipal hospital in Inchon City, were tested to detect the production of Escherichia coli enterotoxin from July to October, 1982. Heat labile enterotoxin (LT) was assayed by Reverse-Passive Latex Agglutination method using Assay kit and heat stable enterotoxin (ST) was assayed by infant mouse assay method.
Enterotoxin were found in 58(17.6%) of 330 patients with diarrhea and 7(10.3%) of 68 healthy children.
From these 58 patients with enterotoxigenic diarrhea, E. coli which produce S.T. alone
were isolated in 23 patients and E. coli which produce L.T. alone were isolated in 9 patients.
In remaining 26 patients, both S.T and L.T were detected.
Most of patients with, enterotoxigenic diarrhea were under the age of three.
Fifty-eight patients with enterotoxigenic diarrhea showed mild clinical features; vomiting
(13.8%), mild fever(24.1%), abdominal pain(36.2%), anorexia(20.7%), and URI like symptom (5%).
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Key Words:
Enterotoxigenic E, coli diarrhea, incidence, childhood.
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