| Clinical Observation of Dds Induced Methemoglobinemia. |
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Hee Seon Auh1, Kwan Hwooy Cho1, Kir Young Kim1, Duk Jin Yun1, Sook Pyo Kwon2 |
1Department of Pediatrics, Yonsei University College of Medicine
2Department of Preventive Medicine and Public Health, Yonsei University College of Medicine |
| D.D.S. 약물로 인한 메트헤모글로빈 혈증에 관한 임상적 연구 |
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魚喜善1, 趙寬棄1, 金吉英1, 尹德鎭1, 權肅約2 |
1연세대학교 의과대학 소아과교실
2연세대학교 의과대학 예방의학교실 |
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| Abstract |
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Various compounds activate the oxidation of hemoglobin. These include nitrites, sulfonamides,
aniline derivatives, chlorates, quinones, acetanilid and phenacetin. The striking offender
has been DDS in infancy and childhood who live in Kangwon Do, Korea.
The common untoward effects of DDS are hemolytic anemia and methemoglobinemia.
This clinical study was carried out for analysis on 57 cases which were diagnosed as DDS
induced methemoglobinemia at the department of pediatrics in Wonju Christian Hospital
during 4 years and 6 months, from Jan. 1, 1977 to June 30, 1981
The results were as follows：
1) DDS induced methemoglobinemia developed in 57 cases among 129 cases of total drugintoxication.
2) The intoxication showed the highest incidence in children before 6 year of age.
3) The dosage ingested was from 25 mg to 250 mg in 32 cases, but others were unknown.
4) Cyanosis occured in all cases.
5) The duration between DDS poisoning and the onset of symptoms was within 6 hours ins 60% of cases.
6) Any case did not show profound anemia.
7) The correlation coefficient was 0. 6 between the dosage and the methemoglobin level.
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| Key Words:
Clinical observation, DDS, Methemoglobinemia |
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