| A Clinical Study on Children with Acute Glomerulonephritis. |
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Jeong Gwon Lee, Dong Jin Lee, Sang Bum Lee, Ja Hoon Koo |
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Department of Pediatrics, Kyungpook National University School of Medicine，Taegu，Korea |
| 소아급성사구체신염에 대한 임상적 관찰 |
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이정권, 이동진, 이상범, 구자훈 |
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경북대학교 의과대학 소아과교실 |
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| Abstract |
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A clinical observation has been made on 104 children with acute glomerulonephritis who
were admitted to pediatric Dept, of Kyung-Pook University hospital during 4 1/2 year period,
from August 1977 to December 1981. Male to female ratio was 1.5 ： 1 and peak incidence was noticed on cold months from November to January when URI was most prevalent. Cases were evenly distributed between.
4 to 12 years of age and affected rate below 3 years of age was quite low(6.5%). URI was the most common preceding illness(66.3%), followed by scarlet fever(4.8%) and impetigo(4.8%). Edema and gross hematuria were observed each in about two third of total cases and hypertension with diastolic BP over 90 mmHg was seen in 50.9%. Chest X-ray with hypertensive patient showed increased pulmonary vascular marking in 86.8%. However
those from normotensive patient showed less involvement in cardiopulmonary status; revealing increased pulmonary vascular marking in 66.7%, pulmonary edema in 27.5% and cardiomegaly in 33.3%.
Laboratory data at the time of admission showed elevated ESR in 75^ and mild anemia in.51%. On urinalysis proteinuria was seen in 65.2% and almost all cases except one showed hematuria. However, RBC cast was seen only 20.2%. ASLO titer over 300 Todd unit was found in 54.4% and serum creatinine and BUN were increased in 43.3% and 36.5% respectively. Serum protein, was decreased in. 30.4%. Serum complement (C3) levels were checked in 83 cases. In 72 cases in whom C3 determination was done with in 2 weeks after onset of illness, it was reduced in almost all case except in 5 cases(6%). However in 3 cases checked after 7 weeks of onset of illness, C3 leveL showed normal value. As complications, acute renal failure and hypertensive encephalopathy were seen in 9 cases respectively, congestive heart failure in 3 cases, secondary nephrotic syndrome in 6 cases,hyponatremia in 16 cases and hyperkalemia in 12 cases. Recovery from acute phase occured within 1st week in 34.1% and about two third of cases were recovered within 2 weeks. In 8 cases (9.4%), acute phase was prolonged over 5 weeks
and 2 cases among this group had intermittent gross hematuria over 1 year, and were subsequently proved to be proliferative glomerulonephritis by renal biopsy.
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| Key Words:
Acute glomerulonephritis, C3 change in acute glomerulonephritis. |
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