| Allogenic bone marrow transplantation in rabbit. |
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Kir Young Kim, Duk Hee Kim, Young Mo Shon, Kwan Sub Chung, Hong Jin Kim, Duk Jin Yun |
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Department of Pediatrics，Yonsei University College of Medicine |
| 가토에서 시행한 동종골수이식에 관한 연구 |
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김길영, 김덕희, 손영모, 정관섭, 김홍진, 윤덕진 |
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연세대학교 의과대학 소아과학교실 |
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| Abstract |
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Allogenic bone marrow transplantation was done with Korean unspecified rabbits. Fresh
bone marrow cell of different sex was infused to the recipient. The study group was divid-
edfive groups according to immunosuppresive drugs.
Each group was consited of 20 rebbits, was exposed to 1200 Rad.
Group A, which were not have bone marrow transplantation, showed 100% mortality rate
after 8 weeks.
Group 8, which did not have immunosuppresive drug, revealed 90% mortality rate Bfter 8
weeks. GVHD was the maincause of death. (87.5%) One rabbit, which survived 1C0 days or
more, had chimerism by chromosome culture.
Group C, which took methotrexate, evealed 80% mortality rate after 8 weeks,also one
rabbit survied 100 days or more, showed chimerism by chromosome culture. Successful
marrow transplantation were 4 rabbits by chromosome culture.
Group D, which received Cyclosporin A, showed 12 rabbits survived5 days or more. Am-
ong them 3 rabbits survived 100 days or more.
Among the cause of death, GVHD was decreased in Group D by comparing with Group B
or C.
We studied optimal range of radiation and found that 1200 Rad was optimal for rabbit.
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| Key Words:
Allogenic bone marrow tranplantation, Graft versus host disease (GVHD), Chimerism,
Immunosuppresion, Total body irvadiation (TBI), Methotrexate, Cyclosporin A.
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