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Effects of Rifampin(RMP) on Liver Function in Tuberculous Children.

Journal of the Korean Pediatric Society 1981;24(5):430-436.
Published online May 15, 1981.
Effects of Rifampin(RMP) on Liver Function in Tuberculous Children.
Hyun Ju Oh, Hyang Suk Yoon, Hyung Suk Bynn, Kyung Yong Huh, Chull Sohn
Department of Pediatrics, College of Medicine, Chonnam National University, Kwangju, Korea.
Rifampin이 소아 결핵 환아의 간기능에 미치는 영향
오현주, 윤향석, 변형석, 허경룡, 손철
전남대학교 의과대학 소아과학교실
To evaluate the hepatotoxicity of RMP in tuberculous children during treatment, liver function tests were performed regularly in 40 children who visited or admitted in Chonnam University Medical School Hospital and Mok-po Children's Tuberculosis Hospital from January 1979 to August 1980. The subjects were divided into three groups according to the administered regimens which were INH+EMB or PAS, INH+RMP(10??15mg/kg) and INH+RMP(16??20)mg/kg respectively. The mean observation period wart 16 weeks and the obtained results were compared between each group which were summerized as follows; 1) Significant increase of serum transaminase activity was noted in the patients who received RMP. 2) Increase of serum transaminase activity developed within 4 weeks after the administration of RMP and the mean value was highest in the second week. 3) The incidence of increased serum transaminase activity was slightly higher in the female subjects. 4) No relationship could be found between the increase of serum transaminase activity and the dosage of RMP. 5) Serum alkaline phosphatase showed no significant difference among three groups. 6) Serum bilirubin concentration was not increased in all subjects.
Key Words: Rifampin, Hepatotoxicity, Serum Transaminase, Tuberculosis

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