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Clinical Obseervation of 12 cases of Kawasaki Disease.

Journal of the Korean Pediatric Society 1981;24(3):245-256.
Published online March 15, 1981.
Clinical Obseervation of 12 cases of Kawasaki Disease.
Bok Yang Pyun, Chang Woo Koh, Dong Whan Lee, Sang Jhoo Lee
Department of Pediatrics,Soon Chun Hyang Medical College Hospital, Seoul, Korea
急性 熱性 皮廣粘膜 淋巴節 症候群에 關한 臨床的 考察
片復陽, 高昌禹, 李東換, 李尙柱
順天鄕大學 醫學部 小兒科學敎室
Kawasaki Disease of Mucocutaneous Lymph Node Syndrome, first described by Kawasaki in 1967, is an acute febrile disease of unknown etiology. Until recently, more than 17,000 cases of this disease have been listed in the survey of a special study group supported by the Japanese Ministry of Health and Welfare. And a number of cases have been reported even outside of Japan including Korea. This disease is of special importance in that 1 to 2% of children suddenly die of it,usually after the acute phase. Twelve cases of Kawasaki Disease who were admitted to Padiatric department, Soon Chun Hyang Medical College Hospital during the period from March 1979 to May 1980, were observed clinically and the following results were obtained. 1.The disease is most prevalent under 2 years of age with predominant in male. 2.Principal clinical features are as follows: 1) Fever lasting from 1 to 2 weeks or more. 2)Diffuse reddening of lips, which become dry, fissured; diffuse erythema of orophayngeal mucosa; strawberry tongue. 3)Polymorphous exanthem of the trunk. 4)Bilateral conjunctival congestion. 5)Initial erythema of the palms and soles with indurative edema followed in the convale- scent stage by striking desquamation beginning in the junction of the nails and skin of the tips of the fingers and toes. 6)Acute nonpurulent enlargement of the cervical lymph nodes. 3. Laboratory abnormalities include leukocytosis with shift to the left, slight decrease in hemoglobin level, increased ESR, positive CRP, proteinuria and pyuria. 4.Other findings include coughing, rhinorrhea, diarrhea and vomiting.5. EKG Showed sinus tachycardia in 5 cases and incomplete bundle branch block in 1 case. But there was no clinical evidence of cardiac abnormalities. 6.Aspirin therapy was performed and there was no remarkable differences in period of fever between two groups of aspirin high and usual dosage group. 7. There was no complication and completely recovered in all cases.
Key Words: Kawasaki disease, clinical observation

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