| A Clinical Study of 15 Cases of Pneumocystis Carinii Pneumonia. |
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Jae Oh Kim1, Sung Sook Cho1, Jung Woo Suk1, Don Hee Ahn1, Keun Chan Sohn1, Tai Hyuk Yim2 |
1Department of Pediatrics, National Medical Center Seoul, Korea.
2Department of Pediatrics, St. Colomban hospital, Choon cheon, Korea. |
| 收容施設 嬰兒에서의 Pneumocystis carinii 肺炎 15例 |
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金載吾1, 趙星淑1, 石正宇1, 安敦姬1, 孫槿贊1, 任太赫2 |
1國立醫療院 小兒科
2春川 성 콜롬반 病院 小兒科 |
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| Abstract |
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Pneumocystis carinii pneumonia is unique infection with unyielding penchant for the debilitated and immunodeficient host. Since several reports of pneumocystis carinii pneumonia in late half of 1950 period, no additional report was found in literature in Korea. We Tecently experienced 15 cases of pneumocystis carinii pneumonia in infants of an institution for foreign adoption, who, were admitted to our*hospital with the chief complaints of dyspnea and cyanosis in two epidemic periods of Feb. 1979 and Marchj 1980.
The clinical review was made.1.Epidemiology: The 1st & 2nd attack rate among infants of institution were 6.1%, 4.1% respectively with higher incidence in premature infants. Patients’ age was almostlybetween2 to 3 months. Many patients were included in low birth weight with poor weight gaining and development. Duration between entrance to the institution and the development of the disease was around 50-60 days. Fatality rate was 33.3%.
2.Presented common symptoms were tachypnea (100%), cyanosis(86.7%), restlessness(66.7%), hacking cough(60.0%) in order of frequency.Respiration rate was over 70/min. in many cases.3.Gas analysis showed low pO2 and O2 saturation. Hematologic and other lab. findings were all within normal limits.4.Chest Xray showed common generalized granular patterns, which were originated at hilus and extended peripherally. Interstitial density was more common than alveolar density.5.Open lung biopsy showed highest positive rate for confirmative diagnosis.6.The effects of trimethoprim-sulfamethoxazole showed good results when started within
1 week after the:onset of symptoms.7.In 5 cases of autopsy, histopathologic findings of all cases were confined to lung and many cysts of pneumocystis carinii were noted in alveolar spaces and interstitium with thickened alveolar septum by Gomeri methenamine silver nitrate stain.
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| Key Words:
Pneumocystis, Pneumonia, infants in institution |
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