| Clinical Eeffects of Ferrocholinate in the Iron Deficiency Anemia of Children. |
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Dong Hwan Lee, Jong Gu Yoon, Kwang Wook Ko |
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Department of Pediatrics, College of Medicine, Seoul National University |
| 小兒 鐵 缺之性 貧血에 對한 Ferrocholinate의 臨床成積 |
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李東煥, 尹鍾求, 高光昱 |
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서울大學校 醫科大學 小兒科學敎室 |
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| Abstract |
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Ferrocholinate, choline citrate iron salt is a new chelate iron which is synthesized by reacting ferric hydroxide with choline dihydrogen citrate. Ferrocholinate is used in the prevention and treatment of microcytic, hypochromic anemias due to iron deficiency. Ferrocholinate does not release high concentrations of free ionic iron in the gastrointestinal tract and clinical reports, although limited, seem to indicate that this drug is better tolerarated than is ferrous sulfate or ferrous gluconate. Ferrocholinate : syrup was administered to 19 patients of iron deficiency anemia. Ferrocholinate was administered orally. Therapeutic dosage was 1.2cc/kg (elementary iron 6mg/kg) divided three times daily. The results were obtained as follows. (Table 1) 1) In this clinical trials, the over-all effective rate was 84.2% 2) There was no effect on 3 cases who have combined with severe infection and congenital heart disease. 3) Of the 19 patients, 2 patients complained transient nausea and 1 patient mild diarrhea. These symptoms, however, disappeared along with continued therapy. |
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