| Clinical Observation on Cerebrospinal fluid Lactic Dehydrogenase Activity. |
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Seung Joo Lee, Hyung Ki Ko, ESook Oh, Don Hee Ahn, Keun Chan Sohn |
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Department of Pediatrics, National Medical Center,Seoul, Korea |
| 뇌척수액내 LDH 활성도의 변동에 대한 관찰 |
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이승주, 고형기, 오의숙, 안돈희, 손근찬 |
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국립의료원 소아과 |
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| Abstract |
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Cerebrospinal fluid lactic dehydrogenase activities with other usual laboratory tests were determined in 131 patients including 48 cases of control group with non-CNS disease and 83 cases of various CNS diseases. Mean value of LDH activity in control group (excluding newborn infants) was 31. 7 unit and in 8 control newborn infants was 54 unit. High levels of CSF LDH activity were found in infectious CNS disorders such as pyogenic meningitis, tuberculous meningitis and non infectious CNS disorders including progressive hydrocephalus, cerebrovascular accident, brain or spinal tumor and metastatic carcinoma. Cerebrospinal fluid LDH activities in aseptic meningitis, Guillain-Barre syndrome, poliomyelitis, epilepsy, chorea and uremia were within normal range. No correlation was found between the levels of CSF LDH activity and the specific etiologic agents or the CSF cell counts and chemistry. Because CSF LDH activity marked the highest level at the extreme of the disease and returned to normal range with recovery of the disease, it is useful as a guidance of antibiotic therapy and an assistant method of prediction
of the prognosis.
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