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Clinical Trial with Sulfamethoxazole-Trimethoprim (Septrin) of Shigellosis in Children

Journal of the Korean Pediatric Society 1973;16(2):137-143.
Published online February 28, 1973.
Clinical Trial with Sulfamethoxazole-Trimethoprim (Septrin) of Shigellosis in Children
Chang Yee Hong
Department of Pediatrics, College of Medicine, Seoul National University Seoul, Korea
細菌性痢疾에 대한 Sulfamethoxazole-Trimethoprim (Septrin)의 效果
洪彰義
서울大學校 醫科大學 小兒科學敎室
Abstract
Forty-two cases of shigellosis in children were treated with sulfamethoxazole-trimethoprim (Septrin) from May 1970 to October 1972. 90% of the patients showed clinical improvement within 2 days and 40 of the 42 patients (95%) within 4 days. On the 25 strains of shigellae, in-vitro sensitivity was tested against eleven antimicrobial agents. Shigella flexneri was the most frequent organism (80%). The percentage of resistant strains to the eleven antimicrobial agents is as follows: Penicillin: 100%, Cioxacillin: 100%, Streptomycin: 92%, Chloramphenicol: 88%, Tetracycline: 88%, Kanamycin: 84%,Erythromycin: 40%,Neomycin: 32%, Ampicillin: 20%, Gentamycin: 0%, SMX/TMP (Septrin) : 0%. All strains of Shigellae tested were highly sensitive to SMX/TMP (Septrin) and Gentamycin.


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