| Clinical Trial with Sulfamethoxazole-Trimethoprim (Septrin) of Shigellosis in Children |
|
Chang Yee Hong |
|
Department of Pediatrics, College of Medicine, Seoul National University Seoul, Korea |
| 細菌性痢疾에 대한 Sulfamethoxazole-Trimethoprim (Septrin)의 效果
|
|
洪彰義 |
|
서울大學校 醫科大學 小兒科學敎室 |
|
|
|
|
| Abstract |
|
Forty-two cases of shigellosis in children were treated with sulfamethoxazole-trimethoprim (Septrin) from May 1970 to October 1972. 90% of the patients showed clinical improvement within 2 days and 40 of the 42 patients (95%) within 4 days. On the 25 strains of shigellae, in-vitro sensitivity was tested against eleven antimicrobial agents. Shigella flexneri was the most frequent organism (80%). The percentage of resistant strains to the
eleven antimicrobial agents is as follows: Penicillin: 100%, Cioxacillin: 100%, Streptomycin: 92%, Chloramphenicol: 88%, Tetracycline: 88%, Kanamycin: 84%，Erythromycin: 40%，Neomycin: 32%, Ampicillin: 20%, Gentamycin: 0%, SMX/TMP (Septrin) : 0%. All strains of Shigellae tested were highly sensitive to SMX/TMP (Septrin) and Gentamycin.
|
|
PDF Links
Download Citation
