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Acute Accidental Isoniazid Poisoning(Report of Two Cases in Children)

Journal of the Korean Pediatric Society 1967;10(3):173-176.
Published online March 31, 1967.
Acute Accidental Isoniazid Poisoning(Report of Two Cases in Children)
Ki Yong Sohn, Young Hwan Chung, Hyun Woo Kim, Mi Na Lee, Keun Soo Lee
Department of Pediatrics, National Medical Center,Seoul Korea
小兒 Isoniazid急性中毒의 2例
孫基勇, 鄭英桓, 金顯宇, 李美那, 李謹洙
With the common use of isoniazid, the problem of accidental poisoning is inevitable in Korea. Only five cases of acute isoniazid poisoning were reported in the English literature until 1963. Since the opening of the National Medical Center in 1958, we have experienced two accidental cases of acute poisoning from an overdose of isoniazid in children. Case 1, a 33-month-old girl, ingested approximately 1,000 mg of isoniazid and developed irritability, flushing, sweating and high fever one and a half hour later; followed by vomiting and convulsions. She was successfully given anti-convulsive drugs and pyridoxine as well as symptomatic treatment. Case 2, a 26-month-old boy, was estimated to have invested 1,200 mg isoniazid and had convuls ions two hours later. The patient was treated with pyridoxine and symptomatically. He recovered, but an electroencephalogram after sedative drugs on the eighth hospital day was interpreted as being "slightly abnormal”. Abnormal physical findings were not detectable when the patient was seen at the out-patient department one month later.

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