| Hydrogen Peroxide Erythrocytes Hemolysis Test and Neonatal Obstructive Jaundice |
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Soon II Lee, Pyung Kil Kim, Duk Jin Yun |
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Department of Pediatrics Yonsei University College of Medicine Seoul, Korea. |
| 신생아 폐쇄성 황달과 H2O2적혈구 용혈검사 |
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이순일, 김병길, 윤덕진 |
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연세대학교 의과대학 소아과학교실 |
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| Abstract |
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Among the prolonged jaundice in the newborn infants, neonatal hepatitis and biliary atresia are
the most common causes of obstructive jaundice. But the differential diagnosis between above two
diseases is difficult some times clinically and simple liver function tests.
Lubin et al. of Boston (1971) has introduced a new helpful method for the differentiation of
two diseases as H2O2 erythrocytes hemolysis test. Authors applied above new method to few cases
of neonatal obstructive jaundice and compared with histologic findings from, needle biopsy specimen.
During 1963 to 1973, 20 cases of neonatal obstructive jaundice patients (16 neonatal hepatitis and
4 biliary atresia) have admitted to Severance Hospital which were confirmed by open cholangiogram
and needle biopsy. Among above 20 cases, two cases of twin babies who were diagnosed as neonatal
hepatitis but remained healthy halves of the twin babies showed also abnormal liver function tests
which suspected latent neonatal hepatitis and evidence of intrauterine infection theory.
New method, H2O2 erythrocytes hemolysis test was simple and very helpful inlhe dfferentiation
between the neonatal hepatitis and the biliary atresia.
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