| On the Permeability of INH through Blood-Brain Barrier |
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Joong Sik Kim1, Young Pyo Hong2 |
1Department of Pediatrics, College of Medicine, Kyung-Hee University
2Department of Internal Medicine, College of Medicine, Kyung-Hee University |
| Isonicotinic acid hydrazide (INH) 의 blood-brain barrier에 대하여 |
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金仲植1, 洪永杓2 |
1慶熙大學校醫科大學 小兒科學敎室
2慶熙大學校醫科大學 內科學敎室 |
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| Abstract |
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Serum and cerebrospinal fluid INH levels were studied in tuberculous and non tuberculous meningitis cases following oral administration of INH 4 mg. per kg. of body weight.
The measurements were done by the biological method. The INH levels 1 hour after administration were about
half of serum in prolonged convulsion and tuberculous meningitis cases.
Two hours after administration, the cerebrospinal fluid levels in normal children showed only one third ofsurum.
Whereas in meningitis and prolonged convulsion cases, the INH levels in cerebrospinal fluid were same
concentration as serum.
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