| Clinical Studies of Typhoid Fever in Children |
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Dong Gwan Han, Tae U Paik, Dong Sik Chin |
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Department of Pediatrics，College of Medicine, Yonsei University |
| 小兒期 腸「티프스」의 臨床的 觀察 |
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韓東觀, 白泰字, 陳東植 |
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延世大學校 醫科大學 小兒科學敎室 |
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| Abstract |
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During the last 10 years which was from January 1957 to December 1966, 73 cases of typhoid
fever was admitted to the Department of Pediatrics, Severance Hospital and evaluated clinically.
The results were obtained as follows;
1) Male was more prominent than female children and the ratio, M：F was 43:30. The peak age
group was from 6 to 10 years(47.9%) and the youngest case was 51 days old boy. The seasonal in-
cidence was prominent in July to September (49%). The 65.1% was admitted within less than 2
weeks after onset of disease. 2) Clinical findings on admission showed fever (100%), abdominal pain (58.9%), anorexia and general malaise (43.8%), nausea and vomiting (42.4%), and diarrhea (39.7%). On the physical
examination, hepatomegaly (58.9%), bradycardia (41.0%), coated tongue (32.8%), abdominal ten-
derness (32.8%), splenomegaly (24. 6%) and rose spots (16.4%) were noted.
The fever and gastrointestinal troubles were predominent comparing adult patients, but abdominal
tenderness, bradycardia, splenomegaly and rose spots were less than adults.
3) Laboratory findings were as follows; Anemia was 50. 6% and absolute leukopenia 9.5% only. The Widal reaction were positive in 83.8% of total 86 tests and the frequency of positive reaction was sharply increased from second week after onset. The positive bacteriological cultures were low in incidence, which were 15.7% of blood, 13.5% of stool and 5% of urine.
4) Clinical response to chloramphenicol with prednisolone was more favorable than chloramphenicol
alone. The average days of defervescence were 5.1 days in chloramphenicol group and 2.4 days in
chloramphenicol combined with prednisolone group.
Respiratory disease (8.2%), intestinal hemorrhage, hepatitis and nephritis were complicated during
the salmonella infections.
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