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Clinical Studies of Typhoid Fever in Children

Journal of the Korean Pediatric Society 1969;12(3):149-158.
Published online March 31, 1969.
Clinical Studies of Typhoid Fever in Children
Dong Gwan Han, Tae U Paik, Dong Sik Chin
Department of Pediatrics,College of Medicine, Yonsei University
小兒期 腸「티프스」의 臨床的 觀察
韓東觀, 白泰字, 陳東植
延世大學校 醫科大學 小兒科學敎室
During the last 10 years which was from January 1957 to December 1966, 73 cases of typhoid fever was admitted to the Department of Pediatrics, Severance Hospital and evaluated clinically. The results were obtained as follows; 1) Male was more prominent than female children and the ratio, M:F was 43:30. The peak age group was from 6 to 10 years(47.9%) and the youngest case was 51 days old boy. The seasonal in- cidence was prominent in July to September (49%). The 65.1% was admitted within less than 2 weeks after onset of disease. 2) Clinical findings on admission showed fever (100%), abdominal pain (58.9%), anorexia and general malaise (43.8%), nausea and vomiting (42.4%), and diarrhea (39.7%). On the physical examination, hepatomegaly (58.9%), bradycardia (41.0%), coated tongue (32.8%), abdominal ten- derness (32.8%), splenomegaly (24. 6%) and rose spots (16.4%) were noted. The fever and gastrointestinal troubles were predominent comparing adult patients, but abdominal tenderness, bradycardia, splenomegaly and rose spots were less than adults. 3) Laboratory findings were as follows; Anemia was 50. 6% and absolute leukopenia 9.5% only. The Widal reaction were positive in 83.8% of total 86 tests and the frequency of positive reaction was sharply increased from second week after onset. The positive bacteriological cultures were low in incidence, which were 15.7% of blood, 13.5% of stool and 5% of urine. 4) Clinical response to chloramphenicol with prednisolone was more favorable than chloramphenicol alone. The average days of defervescence were 5.1 days in chloramphenicol group and 2.4 days in chloramphenicol combined with prednisolone group. Respiratory disease (8.2%), intestinal hemorrhage, hepatitis and nephritis were complicated during the salmonella infections.

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