| Histological Study on Rabbit Liver following Hydrogen Peroxide Enema |
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Tae U Paik |
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Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea |
| 과산화수소 관장이 가토간장에 미치는 영향에 대한 조직학적 연구 |
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白泰宇 |
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연세대학교 의과대학 소아과학교실 |
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| Abstract |
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Since Oliver and Murphy (1920) first administered hydrogen peroxide intravenously for the treatment of influenza pneumonia, attempts have been made to use hydrogen peroxide parenterally as a source of oxygen both in human and in animals. But using hydrogen peroxide intravenously or intraarterially, gas emboli formation by Lorincz, et al. (1948), Stern, et al. (1967) and Feldman, et al. (1967) and methemoglobinemia by Lorincz, et al. (1948)，Feldman, et al. (1967) and Fuson, et al. (1967) were noticed.
Since Olim and Ciuti(1954) described its use in two cases of smeconium ileu, hydrogen peroxide
has been used for the treatment of neonatal intestinal obstruction due to inspissated meconium.
However Ellis and Clatworthy(1966), Danis, et al. (1967) and Shaw, et al. (1967) observed intestinal
gangrene in the newborn infants following colonic lavage with hydrogen peroxide during the surgical
treatment of meconium ileus and they emphasized that this potentially dangerous practice should be
abandoned. Yun(1969) investigated on extrapulmonary oxygenation of hydrogen peroxide in dogs. By his study
for the single administration, 0. 4% hydrogen peroxide could be given with a dose of 10 ml. per kg
of body weight safely by enema preferably without doing any enema before the procedure, which
would give maximum oxygenation in both portal vein and inferior vena cava without forming gas
emboli. Higher than this concentration would cause gas bubbles in portal vein. In the serial administration,
0. 2% hydrogen peroxide could be given by enema alternately exchanging the intestinal
contents with 10 to 15 minutes intervals, preferably with human whole blood (1. 0 ml. per kg. of body weight) to have a prolonged higher oxygenation in portal vein, inferior vena cava and femoral artery, which would not cause gas. emboli in portal vein and methemoglobinemia.
Author studied the histologic study on rabbit liver by enema of normal saline solution as a control,
0.25% and 0.75% hydrogen peroxide with the amount of 10 cc per kg of body weight singly or
serially (six times with 15 minutes of interval) to know whether these groups, which developed
emboli or not, are harmful to the liver or not. It was known that only 0. 75% hydrogen peroxide
enema group showed gas emboli in the mesenteric vein, portal vein and vessels of liver and all the
experimental groups didn’t show any histologic abnormalities in the liver such as cloudy swelling,
inflammation, air emboli, congestion and glycogen change. From the result of this experiment,
since visible gas in portal veindid not cause any minor tissue damage in the liver, hydrogen peroxide
solution which would not form gas emboli in portal vein, could be used clinically without danger
because the solution increases PO2 in venous and arterial blood significantly.
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