| Clinico-Pathological Evaluation of Hepatomegaly in Childhood (emphasized on the needle biopsy finding of hepatomegaly unknown etiology)
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Chung-Kyu Kim, Chui-Hee Lee, Du-Bong Lee |
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Department of Pediatrics, Catholic Medical College Seoul, Korea |
| 소아기 간종대의 임상병리학적 관찰 (특히 원인불명 성간종대 에 관하여) |
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김정규, 이철희, 이두봉 |
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가톨릭의과대학 소아과학교실 |
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| Abstract |
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In this study, authors attempted to evaluate the hepatomegaly without any clinical symptoms of
liver disease in childhood. Thirty children were selected for this study, their age distribution was
from three years to fifteen years of life. Ten, nine and eleven cases of these subjects had the enlarged
liver over 4. 5 cm, 3. 5 cm to 4. 0 cm., and below 3. 5 cm. below right costal margin respectively.
The liver biopsy used by Menghini’s needle was performed in all cases with liver function tests,
and the histologic findings were compared to the results of biochemical studies.
The results were as follows;
1. The results of liver function studies showed the elevation of Thymol Turbidity Test in fifteen
cases and the increased the serum globlin fraction in twenty-five cases. But there was no correlation
between chronic active hepatitis and the abnormal liver function tests. 〜
2. Six children had chronic active hepatitis which proven histologically by needle biopsy. Four of
them had either a history of acute hepatitis or clinical evidence of liver disease and two children
were in state of malnutrition.
3. Four in eleven children who had malnutrition showed the histologic findings of diffuse fatty liver.
4. The histologic findings of nonspecific reacitve hepetitis had seen in seven and they had eitermalnutrition, nephritis, upper respiratory infection or heart disease.
Through this histo-pathologic snudy authors has been impressed that First; Children’s liver showed
physiologically more actively regenerative than adult’s liver. This evidence may play a role in hepatomegaly
in non-liver diseased children. Second; The incidence of chronic active hepatitis and fatty
liver in this series may suggest that considerable number of children has the possibility of progressive
liver damage going to chronic active hepatitis after an acute episode of hepatitis in childhood.
Third; Diagnostic significance of needle biopsy of the liver in children who had the questionable
hepatomegal was approval.
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