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A Case of Letterer-Siwe Disease.

Journal of the Korean Pediatric Society 1965;8(2):51-56.
Published online May 31, 1965.
A Case of Letterer-Siwe Disease.
Kir Young Kim, Ki Young Lee, Kook Hoon Ko, Geukdong KO
Dept, of Pediatrics Yonsei Medical School
Letterer-Siwe氏病의 一1 例
金吉英, 李琦寧, 金鍾源, 高克勳
延世大學校 醫科大學 小兒科學敎室
This is a report of a 10 months-old male with Letterer-Siwe disease. The patient illustrated the classical clinical features of the disease, including maculopapular rash, hemorrhagic manifestations, anemia,diarrhea, marked enlargement of the spleen & liver, and susceptibility to secondary infection. Most of these signs developed soon after birth. (Fig. 1,2, & 3) Diagnosis was confirmed by microscopic examination, of skin biopsy and bone marrow aspiration. (Fig. 4 & 5) The patient received intensive antibiotic and corticosteroid therapy without improvement.

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