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Original Article
The Effect of Tumor Necrosis Factor-α in Cultured Neonatal Rat Cardiomyocytes
Su Jin Kim, Dong Seok Lee, Ok Ko, Il Soo Mun, Bok Hyun Ko, Yong Wook Jung
Clin Exp Pediatr. 2001;44(11):1262-1268.   Published online November 15, 2001
Purpose : Tumor necrosis factor-α(TNF-α) is a pro-inflammatory cytokine that has been implicated in the pathogenesis of cardiovascular disease. Serum levels of TNF-α are elevated in many human cardiac related pathogenic conditions, including heart failure. It is well known that TNF-α inhibits myocardial contractility and induces apoptosis of adult rat cardiomyocytes via stimulation of TNF receptor 1. But pathophysiologically relevant...
Experssion of the NR2A and 2B Subunits of N-Methyl-D-aspartate Receptors in Hypoxic Neonatal Rat Hippocampus
Jong Su Lee, Dong Seok Lee, Jung hyun Park, Il Soo Moon, Bok Hyun Ko, Yong Wook Jung
Clin Exp Pediatr. 2001;44(4):433-442.   Published online April 15, 2001
Purpose : The developing brain has been reported to be extremely susceptible to toxicity of ischemia and/or hypoxia during a restriced developmental period. Hippocampal neuronal cell death is a typical type of perinatal hypoxic brain lesion and often coexists with other forms of cerebral hypoxic injuries. In the present study, we examined whether transcriptional changes of NR2A and NR2B subunits...