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Review Article
Hematology
Diffuse alveolar hemorrhage and recombinant factor VIIa treatment in pediatric patients
Jeong A Park
Clin Exp Pediatr. 2016;59(3):105-113.   Published online March 31, 2016

Diffuse alveolar hemorrhage (DAH) is a life-threatening pulmonary complication in patients with hematologic malignancies or autoimmune disorders. The current treatment options, which include corticosteroids, transfusions, extracorporeal membrane oxygenation (ECMO), and immunosuppressants, have been limited and largely unsuccessful. Recombinant activated factor VII (rFVIIa) has been successfully administered, either systemically or bronchoscopically, to adults for the treatment of DAH, but there are...