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Purpose : Down syndrome, the most common single cause of mental retardation, is usually due
to meiotic nondisjunction leading to trisomy 21. In order to understand the mechanisms of meiotic
nondisjunction including parental origin of an extrachromosome and the meiotic stage of
nondisjunction, we have studied DNA polymorphisms at loci on the long arm of chromosome 21 in
36 families with free trisomy 21.
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