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Normal IgG is now divided into four subclasses; IgGl, IgG2, IgG3 and IgG4. Each subclass has its
unique characteristics. The different subclass compositions of antibodies are raised in humans against
different immunogenic materials such as vaccinations or microoraganisms. All the IgG subclasses are
reported to be transferable from mother to fetus through the placenta, but there have been some
controversies in case of IgG2.
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