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Original Article
Nephrology (Genitourinary)
Variation in clinical usefulness of biomarkers of acute kidney injury in young children undergoing cardiac surgery
Hee Sun Baek, Youngok Lee, Hea Min Jang, Joonyong Cho, Myung Chul Hyun, Yeo Hyang Kim, Su-Kyeong Hwang, Min Hyun Cho
Clin Exp Pediatr. 2020;63(4):151-156.   Published online February 5, 2020
Question: Can clinical usefulness of biomarkers of acute kidney injury vary on the clinical circumstances?
Finding: In young children undergoing cardiac surgery, urine KIM-1/Cr level peaked at 24 hours with significant difference from baseline level and was significantly higher at 6 hours in the AKI group. However, urine NGAL/Cr and IL-18/Cr levels showed no specific trend with time for 48 hours after cardiac surgery.
Meaning: Urine KIM-1/Cr concentration could be considered a good biomarker for early AKI prediction after open cardiac surgery in young children.
The Study of Serum Troponin I and CK-MB in the Acute Stage of Kawasaki Disease
Minshik Kim, Yoonae Chun, Youngok Lee, Namji Cho, Kyungsook Kim
Clin Exp Pediatr. 1998;41(5):695-700.   Published online May 15, 1998
Purpose : The pathogensis and etiologic agents are still unknown but clinical studies suggest that Kawasaki disease(KD) is an autoimmune disease caused by infectious agents associated with the early development of acute myocarditis and coronary artery abnormalities. The study investigates serum troponin I(cTnI) and creatine kinase(CK)-MB in the acute stage of KD before diagnosis the use of intravenous immunoglobulin(IVIG) treatment...