| A Case of Neonatal Hypothyroidism due to Maternal TSH-Binding Inhibitor Immunoglobulin |
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Myung Lye Kim, Rhie Choi, Dong Hwan Lee, Sang Jhoo Lee |
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Department of Pediatrics, College of Medicine, Soonchunhyang University, Seoul, Korea |
| 산모로부터 이행된 TSH-Binding Inhibitor Immunoglobulin에 의해 발생한 신생아 갑상선 기능 저하증 1례 |
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김명례, 최리, 이동환, 이상주 |
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순천향대학교 의과대학 소아과학교실 |
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| Abstract |
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Neonatal screening for congenital hypothroidism is important because of the possibility that mental retardation may be avoided if treatment started early.
A 1 day old patient was admitted to our department of Pediatrics for congenital hypothyroidism screening. The mother was 33 years old and had been on thyroid replacement therapy since 32 years of age. During the pregnancy she was euthyroid and had 83.4% of TSH-binding inhibitor immunoglobulin. The hypothyroidism was characterized by low T4 levels(3.04 ㎍/dl), elevated TSH(50μU/ml) and delayed bone age.
At 3 days of age, the baby was started on thyroxine treatment. Thyroxine substitution was withdrawn for 1 week at 26 months of age, laboratory signs of hypothyroidism reappeared. On the thyroid scan, it was decreased uptake function of both thyroid glands. So thyroxine has been readministering till now and the patient is under close observation. |
| Key Words:
Hypothyroidism, TBII |
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