| Effects of Adriamycin on Membrane Potential and Intracellular Sodium Activity in Canine Purkinje fibers |
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Chan Uhng Joo1, Soo Wan Chae2 |
1Department of Pediatrics, College of Medicine, Chonbuk Nation University, Chonbuk, Korea
2Department of Pharmacology, College of Medicine, Chonbuk Nation University, Chonbuk, Korea |
| 항암제 Adriamycin®이 개심장 Purkinje fibers의 막전위 및 세포내 Na 이온 활성도에 미치는 영향 |
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주찬웅1, 채수완2 |
1전북대학교 의과대학 소아과학교실
2전북대학교 의과대학 약리학교실 |
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| Abstract |
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Anthracycline antibiotic adriamycin (doxorubicin) is presently considered to be a very effective chemotherapeutic agent in the treatment of many human tumors. Adriamycin induced cardiomyopathy limits its clincal use. A number of hypotheses have been proposed to explain the mechanism of cardiotoxicity with adriamycin, but none has yet been demonstrated. The effects of adriamycin on membrane potential and intracellular sodium ion activity in isolated canine Purkinje fibers were studied.
The results obtained as follows.
1) Adriamycin induced hyperpolarization in diastolic membrane potential and prologed the duration of the action potential.
2) Adriamycin increased intracellular sodium ion activity.
3) With the pretreatment of ouabain, the alterations of the membrane potentials and the increased intracellular sodium ion activity caused by adriamycin were inhibited.
From above results, it was suggested that the changes of the membrane potential caused by adriamycin may be the result of a drug-induced alteration in membrane coductance to K+, and that adriamycin may be a inhibitor of the Na+-K+ ATPase in isolated canine Purkinje fibers. |
| Key Words:
Adriamycin, Membrane potential, Intracellular sodium ion activity, Purkinje fibers |
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