| The effects of adriamycin on twitch force and membrane potential in an isolated Guinea-pig papillary muscle. |
|
Chan Uhng Joo1, Pyung Han Hwang1, Jung Soo Kim1, Hee Cheol Yu2, Soo Wan Chae2 |
1Department of Pediatrics, College of Medicine, Chonbuk National University, Chonbuk, Korea
2Department of Pharmacology, College of Medicine, Chonbuk National University, Chonbuk, Korea |
| Adriamycin이 기니피그 유두근의 수축력 및
막전위에 미치는영향 |
|
주찬웅1, 황평한1, 김정수1, 유희철2, 채수완2 |
1전북대학교 의과대학 소아과학교실
2전북대학교 의과대학 약리학교실 |
|
Received: 28 October 1990 • Accepted: 28 December 1990 |
|
|
| Abstract |
|
The antiumor antibiotic adriamycin is presently considered to be a very effctive and useful
chemotherapeutic agent in the treatment of many human tumors. Cardiotoxicity of adriamycin limits
its clinical use. A number of hypotheses have been proposed to explain the mechanism of cardiotox-
icity with adriamycin, but none has yet been demonstrated.
The effects of adriamycin on twitch force and membrane potential in an isolated guinea-pig
papillary muscle were studied.
The results obtained as follows.
1) Adriamycin produced a positive inotropic effects in isolated beating papillary muscle.
2) Adriamycin induced hyperpolarization in diastolic membrane potential in papillary muscle.
3) Despite of the pretreatment of 10~5M propranolol, the positive inotropic effects and hyperpolar-
ization in diastolic membrane potential caused by adriamycin were not abolished.
From avove results, it was suggested that the mechanism of the positive inotropic effect and
hyperpolarization in diastolic membrane potential caused by adriamycin does not involve 0-
adrenergic stimulation in isolated guinea-pig papillary muscle. |
| Key Words:
Adriamycin, Cardiotoxicity, Contractillity, Membrane potential, Papillary muscle |
|
PDF Links
Download Citation
