| Inteleukin-6 Level in Systemic Lupus Erythematosus |
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Young Nae Yim1, Dong Soo Kim2 |
1Department of Pediatrics, Kanghwa Community Hospital, Kanghwal, Korea
2Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea |
| 전신성 홍반성 낭창 환자에 있엇 Interleukin-6의 과잉 생성에 관한 연구 |
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임영내1, 김동수2 |
1강화병원 소아과
2연세대학교 의과대학 소아과학교실 |
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| Abstract |
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Systemic lupus erythematousus(SLE) is a disease affecting blood vessels and connective tissue, which are damaged by deposition of pathogenic autoantibodies and immune complexes.Although a complex disease, SLE provides a number of insights into autoimmune pathogenesis. Autoimmune disease, in general, is characterized by B cell hyperactivity which results in hypergammaglobulinemia and production of a variety of autoantibodies reactive to organ-nonspecific antigens such as DNA, RNA, and cell membrane structures. SLE patients usually show a marked increase in the number of activated and immunoglobulin-producing circulating B cells. Recently, cytokines with specific effects on immune regulating have been detected and extensively studied. One of them, Interleukin-6(IL-6), is an activated monocyte derived factor which stimulates B cell growth and differentiation.
We investigated the serum IL-6 levels of SLE patients in an attempt to demonstrate their relationship with the patient's clinical manifestation, and the serum levels of C-reactive protein(CRP), circulating immune complexes(CIC2), and soluble interleukin-2 receptor(sIL-2R).
The study subjects consisted of 22 patients with SLE who had visited SeveranceHOspital from July 1986 to September 1987 and 10 normal controls. The patient's sera were stored at -70℃ and later analyzed.
The serum levels of IL-6 were measured by ELISA method with Inter Test-6X Human IL-6 ELISA kit ; the serum CRP levels by flurorescence polarization immunoassay ; the serum CIC levels by solid phase Clq binding assasy ; and the serum sIL-2R levels by ELISA metod.
The results were as follows :
The mean serum IL-6 level of SLE patient(1,366pg/ml) was higher than that of the controls (98 pg/ml)(P<0.05). Among the SLE patients studies, the mean serum IL-6 level was higher in those with vasculitis than those without. In the SLE patients studied, a linear correlation was present between the measured serum IL-6 and level and platelet count. The mean sIL-2R level of the SLE patients studied, no correlation was present between the serum IL-6 and sIL-2R levels measured.
The high serum IL-6 level might play an important role int the pathogenesis of SLE. |
| Key Words:
Systemic lupus erythematosus, Autoimmune disease, Interleukin-6 |
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