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Changes of Serum IgG4 in Allergic Patients

Journal of the Korean Pediatric Society 1993;36(3):403-408.
Published online March 15, 1993.
Changes of Serum IgG4 in Allergic Patients
Soo Young Cho, Sun Kyu Park, Pyoung Han Hwang, Jung Soo Kim
Department of Pediatrics, Chonbuk National University Medical School, Chonju, Korea
알레르기 환자에서 혈청내 IgG4의 변화
조수영, 박선규, 황평한, 김정수
전북대학교 의과대학 소아과학교실
This study ws performed to evaluate the changes of serum IgG4 level in children with allergic diseases. Serum IgE, IgG and IgG4 level were measured using enyzme immunoassay(IgE) and radial immunodiffusion method (IgG and IgG4) in 21 children with bronchial asthma, allergic rhinitis or urticaria. Eosinophil counts in peripheral blood and the values fo serum IgE were significantly increased in allergic patients. The values of IgG4 in allergic patients were also increased compare to those in controls(24.23mg/dl versus 20.33mg/dl). But the values of IgG4 were not significantly correlated to either IgG r IgE levels.Further studies will be needed for measuring allergen specific IgE and IgG4 levels considering the onset of diseases, methods and duration of treatment.
Key Words: Allergy, IgG4

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