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A Clinical Study of Neonatal Sepsis

Journal of the Korean Pediatric Society 1993;36(6):771-777.
Published online June 15, 1993.
A Clinical Study of Neonatal Sepsis
Hyoung Shim Chang, Jung Sook Park, Young Ho Lee, Ahn Hong Choi
Department of Pediatrics, Dong-A University School of Medicine, Pusan, Korea
신생아 패혈증에 관한 임상 연구
장형심, 박정숙, 이영호, 최안홍
동아대학교 의과대학 소아과학교실
The 35 newborns with neonatal sepsis admitted to the Neonatal Intensive Care Unit of Dong-A Univesity Hospital during 2 years and 6months from April 1990 to October 1992, and were reivewed on the bases of incidence, clinical manifestations, underlying conditions, etiologic organisms, results of antibiotics sensitivity test and mortality rate. The result were summarized as follows; 1) The incidence of neonatal sepsis was 1.2% and male predominated. Sepsis was more prevalent in premature babies(7.5%) than in full term babies(0.8%) 2) Neonatal sepsis occured more frequently in low birth weight infant below 2500g(6.3%) than in normal birth weight infant 3) Underlying conditions associated with neonatal sepsis were as follows: pneumonia(25.7%), HMD(17.1%), urinary tract infection(11.4%), DIC(8.6%). 4) Common clinical manifestations obsesved in neonatal sepsis were jaundice(45.7%), poor feeding(22.9%), abdominal distension(20.0%), lethargy, convusion, apnea and diarrhea in order. 5) Blood culture report revealed that gram negative organisms(57.1%) were more frequently associated with neonatal sepsis than gram positive oranisms(37.1%), Klebsiella pneumoniae was the most common microorganisms in neonatal sepsis 6) Vancomycin(100%), cephalothin(84.6%) and chloramphenicol(84.6^)were the wsensitive drug to gram positive organisms, Gram negative organisms were sensitive to amikacin(100%), and cephalothin(95%) 7) Overall mortality rate was 17.1% in all parients with neonatal sepsis, 7.7% in gram positive sepsis and 25% in gram negative sepsis. We conclude tha the etiologic organisms of neonatal sepsis have been altered. and have to choose appropriate antibiiotics which particularly sensitive to these gram negative organisms such as Klebsiella pneumoniae, Pseudomonas aeruginosa, and also have to specify antibiotics according to the predominant organisms of the each institute.
Key Words: Neonatal Sepsis

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