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Hand, Foot and Mouth Disease Associated with the Aseptic Meningitis in Seoul, 1990

Journal of the Korean Pediatric Society 1993;36(6):842-849.
Published online June 15, 1993.
Hand, Foot and Mouth Disease Associated with the Aseptic Meningitis in Seoul, 1990
Young Ah Lee, Sei Ho Oh, Soo Jong Hong, Young Hwue Kim, Hyung Nam Moon, Chang Yee Hong
Department of Pediatrics, College of Medicine, University of Ulsan, Seoul, Korea
수족구병의 임상적 고찰 -뇌막염을 중심으로-
이영아, 오세호, 홍수종, 김영휘, 문형남, 홍창의
울산대학교 의과대학 소아과학교실
We performed clinical and virological studies on 79 children with hand, foot and mouth disease(HFMD) who had been admitted or visited to the department of Pediatrics, Asan Medical Center from February to August, 1990. The results were as follows; 1) There were total of 79 cases with hand, foot and mouth disease during this period. The aseptic meningitis was combined in 18cases(22.8%) 2) The male-to-female ratio of HFMD was 2.03 to 1, but that of aseptic meningitis was 8 to 1. 3) Hand, Foot and mouth disease occureed more frequently in under the age of 5 years, and the aseptic meningitis in under the age of 1 year. 4) Hand, foot and mouth disease and the aseptic meningitis occureed mostly in May and June 5) In addition to the skin maifestations characteristic in hand, foot and mouth disease, some of the patients with aseptic meninitis han the following symptoms: change of consiousness, seizure, monoparesis in the upper extrmity, paraparesis in the lower extremity. 6) The causative agent of hand, foot and mouth disease associated with the aseptic meningitis in Seoul in 1990 seemed to be enterovirus 71 according to the serologic study.
Key Words: Hand, foot and mouth disease, Aseptic meningitis, Enterovirus 71

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