| The Effectf Zonisamide in Children with Refractory Epilepsies |
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Ki Joong Kim, Soo Ahn Chae, Tae Sung Ko, Dong Wook Kim, Yong Seung Hwang |
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Department of Pediatrics, Seoul National University, College of Medicine, Seoul, Korea |
| 난치성 소아간질 환자에서 Zonisamide의 효과에 대한 연구 |
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김기중, 채수안, 고태성, 김동욱, 황용승 |
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서울대학교 의과대학 소아과학교실 |
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| Abstract |
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Zonisamide was amministered to 20 patients with refractory epileptic seizures. The mean duration of the administration was 6 months, and the mean dosage was 7.2mg/kg/day. The efficacy of zonisamide was rated remarkable in 15% of the cases, improvement in 40%, and no change in 45%.
The response rates of zonisamide were 62.5% for myoclonic seizures, 50% for tonic-clonic seizures, 80% for atonic seizures and 33.3% for atypical absence seizures. There was no correlation between the clinical response and dose or serum concentration of the drug. The adverse effects were observed in 35% of the cases which were drowsiness, dizziness, ataxia, nausea, and vomiting. In all cases, however, the administration of zonisamide could be continued. |
| Key Words:
Zonisamide, Refractory epilepsies |
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