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Captopril in Children with Renovacular Hypertension.

Journal of the Korean Pediatric Society 1985;28(1):58-67.
Published online January 31, 1985.
Captopril in Children with Renovacular Hypertension.
Yong Choi, Hoan Jong Lee, Hee Young Shin, Kwang Wook Ko, Chang Yee Hong
Dept, of Pediatrics,College of Medicine,Seoul National University
소아 신혈관성 고혈압 (Renovascular Hypertension) 에 대한 Captopril 의 치료효과
최 용, 이환종, 신희영, 고광욱, 홍창의
서울대학교 의과대학 소아과
Captopril, a kind of converting enzyme inhibitors, is a promising anti-hypertensive drug, which is developed recently, and studied mainly in adult patients. We administered captopril to 4 children with renovascular hypertension, three of them accompanied Takayasu's arteritis and the remainder had isolated lesion. Three to five times of initial trials were performed on each patient with 12.5 mg of captopril. Blood pressure decreased from 160±19.3/112±ll. 1 mmHg to 124±16.0/86±11.0 with test doses(p<0.01,by paired t-test), the time to nadir ranged from 74 to 95 minutes. With dosage adjustment of captopril and addition of propranolol and/or hydrochlorthiazide, stable blood pressures at normal values were recorded within 1 to 3 weeks. They are on follow-up for 9 to 20 months(mean 13.5 months) with good results. Three of the four patients showed some resistance during early phase of captopril the rapy, though the response to the first dose was remarkable. There was no significant adverse reaction except transient elevation of creatinine in one patient with bilateral renal artery involvement. With the above result, we can conclude that captopril can be safely used for renovascular hypertension resistent to conventional antihypertensive therapy in children either.
Key Words: Takayasu's arteritis, Renovascular hypertension, Captopril, Converting enzymeinhibitor

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